Title:Role of Azoles in Cancer Prevention and Treatment: Present and Future Perspectives
Volume: 18
Issue: 1
Author(s): Khurshid Ahmad, Mohd Kalim A. Khan, Mohammad Hassan Baig*, Mohd Imran and Girish Kumar Gupta*
Affiliation:
- Department of Medical Biotechnology, Yeungnam University, Gyeongsan,Korea
- Department of Pharmaceutical Chemistry, M. M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala-133207, Haryana,India
Keywords:
Azoles, cancer, treatment, prevention, anti-HIV, derivatives.
Abstract: Background: Cancer has gradually become one of the leading causes of death worldwide. The
incidence of cancer among the population has increased alarmingly over the last two decades, primarily due to
an increasing population of immune-compromised patients and the continuing rise in anti-cancer drug
resistance. Azole found privileged structure in medicinal chemistry and pharmaceutical industry and also found
to be showing antioxidant; antimicrobial, anthelmintic, anticancer, antiviral, anti-parasitic, anti-inflammatory,
anti-HIV, and antihypertensive activities.
Objective: In this review, we highlight some areas of current interest in context to azoles and their derivatives as
potential chemotherapeutic agents and inhibitors.
Method: A comprehensive literature search was performed for writing this review. An updated view on different
derivatives of azoles and use in cancer management has been discussed.
Results: Here we have discussed the present scenario of azoles and their derivatives as potential
chemotherapeutic agents and inhibitors. Along with, the future perspectives of azoles in cancer prevention and
treatment are also discussed.
Conclusion: The information provided in this review might be useful to researchers in designing of novel and
potent multifunctional azole analogues for the treatment of cancer and other multifactorial diseases.
