Title:Design and Synthesis of 1,4-dihydropyridine Derivatives as Anti-cancer Agent
Volume: 17
Issue: 7
Author(s): Denish Viradiya, Sheefa Mirza, Faraz Shaikh, Rajesh Kakadiya*, Anand Rathod, Nayan Jain, Rakesh Rawal*Anamik Shah*
Affiliation:
- Center of Excellence, National Facility for Drug Discovery Center, Department of Chemistry, Saurashtra University, Rajkot,India
- Gujarat Cancer Research Institute, Asarwa, Ahmedabad, Gujarat,India
- Center of Excellence, National Facility for Drug Discovery Center, Department of Chemistry, Saurashtra University, Rajkot,India
Keywords:
Anticancer activity, antipoliferative activity, benzylpyridinium salt, 1, 4-dihydropyridine, MTT assay.
Abstract: Aims: A series of 1,4-dihydropyridine based compounds bearing benzylpyridinium moiety have been
designed and evaluated for in vitro anticancer activity against glioblastoma U87MG, lung cancer A549 and
colorectal adenocarcinoma Caco-2 cell lines using the MTT assay.
Method: Among these compounds, 7b, 7d, 7e, and 7f exhibited potent anticancer activity against the cell lines
tested. The cytotoxicity of the synthesized derivatives was compared to standard drugs (carboplatin, gemcitabine, and
daunorubicin).
Result: Thus, synthesized 1,4-dihydropyridines can be considered as the encouraging molecules for further drug
development as anticancer agents.
