Title:Nontraditional Cardiovascular Risk Factors in Pediatric Type 1 Diabetes
Volume: 13
Issue: 6
Author(s): Robert P. Hoffman*
Affiliation:
- Nationwide Children's Hospital ED422, 700 Children’s Drive, Columbus, OH 43205,United States
Keywords:
Biochemical markers, cardiovascular, pediatric, risk factors, type 1 diabetes, inflammation.
Abstract: Background: If we are to gain a full and complete understanding of mechanisms of cardiovascular
risk factors in adolescent type 1 diabetes mechanistic risk markers must be developed that
predict risk accurately and which can be used as endpoints for short or intermediate term intervention
studies aimed at reducing risk. A variety of biochemical and vascular markers have potential to meet
these requirements. Biochemical markers include markers of inflammation, oxidation, and endothelial
damage. Vascular markers include static and dynamic measures of arterial function. Adolescents with
type 1 diabetes demonstrate alterations in many of these markers.
Conclusion: For many of the biochemical markers precise cut-off points with high sensitivity and
specificity are not available and many of the vascular measures require specific equipment and are operator
dependent.
