Title:Biofilm-mediated Antibiotic-resistant Oral Bacterial Infections: Mechanism and Combat Strategies
Volume: 23
Issue: 14
Author(s): Indulata Kanwar, Abhishek K. Sah and Preeti K. Suresh*
Affiliation:
- University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh,India
Keywords:
Dental caries, periodontal disease, anti-biofilm approaches, antibiotic.
Abstract: Oral diseases like dental caries and periodontal disease are directly associated with the capability of
bacteria to form biofilm. Periodontal diseases have been associated to anaerobic Gram-negative bacteria forming
a subgingival plaque (Porphyromonas gingivalis, Actinobacillus, Prevotella and Fusobacterium). Biofilm is a
complex bacterial community that is highly resistant to antibiotics and human immunity. Biofilm communities
are the causative agents of biological developments such as dental caries, periodontitis, peri-implantitis and causing
periodontal tissue breakdown. The review recapitulates the latest advancements in treatment of clinical
biofilm infections and scientific investigations, while these novel anti-biofilm strategies are still in nascent phases
of development, efforts dedicated to these technologies could ultimately lead to anti-biofilm therapies that are
superior to the current antibiotic treatment. This paper provides a review of the literature focusing on the studies
on biofilm in the oral cavity, formation of dental plaque biofilm, drug resistance of bacterial biofilm and the antibiofilm
approaches as biofilm preventive agents in dentistry, and their mechanism of biofilm inhibition.
