Title:The Roles of the Unique Prolyl Isomerase Pin1 in Cancer-Related Viral and Bacterial Infections
Volume: 16
Issue: 9
Author(s): J. Wang, X.-H. Liao, M. Zheng, D. Yang, X. Z. Zhou, H. Liu and K. P. Lu
Affiliation:
Keywords:
Prolyl isomerase Pin1, cancer-related viral and bacterial infections, ATRA, inflammatory response, NF-
κB, Toll-like receptors.
Abstract: Infection is the process of pathogen invasion, as well as the host
reaction to the foreign agents. Proline-directed phosphorylation is a major
regulatory mechanism that regulates the function of fundamental proteins
involved in infection and infection-induced cancer. Recently, the
identification of the phosphorylation-dependent prolyl isomerase Pin1 has
uncovered a unique regulatory signaling mechanism controlling protein
conformation and function after phosphorylation. Pin1 is the only proline
isomerase that specifically recognizes certain Pro-directed Ser/Thr
phosphorylation motifs. Pin1 has emerged as a major regulator of cancerrelated
viral and bacterial infections notably via activating Toll-like receptor
signaling and NF-κB pathways. This paper will specifically review recent findings on the role
of Pin1 in cancer-related viral and bacterial infections and also discuss newly discovered
Pin1 inhibitors as promising drugs for the prevention and treatment of viral and bacterial
infections and associated tumorigenesis.
