Title:Structure-activity Relationship Studies of New Marine Anticancer Agents and their Synthetic Analogues
Volume: 24
Issue: 42
关键词:
海洋天然化合物，抗癌活性，结构 - 活性关系（SAR）研究，生物碱，甙类，萜类化合物，类固醇。
摘要: This review addresses in-depth recent structure-activity relationship (SAR) studies
published in 2015 on new marine compounds and their synthetic analogues with potential or
established anticancer activity. Priority was given to papers on in vitro screening methods of
marine-derived bioactive compounds, usually performed using panels of human cancer cell
lines, as a first step of the anticancer drugs discovery process. Our review describes compounds
belonging to different classes of substances, namely terpenoids, glycosides, alkaloids,
steroids, as well as other small molecular compounds. We believe that our review will not
only help chemists in the design and synthesis of novel anticancer compounds possessing
specific cytotoxic or cytostatic activity in human cancer cells, but will also extend the existing
databases comprising data on bioactivity of marine natural compounds.
