Title:Structure-activity Relationship Studies of New Marine Anticancer Agents and their Synthetic Analogues
Volume: 24
Issue: 42
Author(s): Sergey N. Fedorov*, Valentin A. Stonik, Friedemann Honecker and Sergey A. Dyshlovoy
Affiliation:
- Laboratory of Marine Natural Products Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far-East Branch, Russian Academy of Sciences, Prospect 100-let Vladivostoku 159, Vladivostok 690022,Russian Federation
Keywords:
Marine natural compounds, anticancer activity, structure-activity relationship (SAR) study, alkaloids,
glycosides, terpenoids, steroids.
Abstract: This review addresses in-depth recent structure-activity relationship (SAR) studies
published in 2015 on new marine compounds and their synthetic analogues with potential or
established anticancer activity. Priority was given to papers on in vitro screening methods of
marine-derived bioactive compounds, usually performed using panels of human cancer cell
lines, as a first step of the anticancer drugs discovery process. Our review describes compounds
belonging to different classes of substances, namely terpenoids, glycosides, alkaloids,
steroids, as well as other small molecular compounds. We believe that our review will not
only help chemists in the design and synthesis of novel anticancer compounds possessing
specific cytotoxic or cytostatic activity in human cancer cells, but will also extend the existing
databases comprising data on bioactivity of marine natural compounds.
