Title:Sulfamic Acid-catalyzed One-pot Multicomponent Synthesis of 5-phenyl-2- thioxo-1,2,3,5-tetrahydro-4H-pyrimido[4,5-d][1,3]thiazolo[3,2-a]pyrimidin- 4-ones
Volume: 3
Issue: 3
Author(s): Sunetra Jadhav, Ajinkya Patravale, Reshma Patil, Digambar Kumbhar, Vishram Karande, Dattatray Chandam and Madhukar Deshmukh*
Affiliation:
- Department of Agrochemicals and Pest Management, Shivaji University, Kolhapur, M.S.,India
Keywords:
2-Aminothiazole, 2-thiobarbituric acid, thiazolopyrimidine derivatives, sulfamic acid, atom economy, multicomponent
reaction.
Abstract: Background: A straightforward protocol for the one-pot synthesis of a series of novel thiazolopyrimidine
derivatives has been developed.
Method: In which multicomponent reaction between thiobarbituric acid, 2-aminothiozole and several
substituted aldehydes using sulfamic acid (20 mol%) as a heterogeneous and easily recoverable catalyst
in ethanol under reflux condition.
Conclusion: This method has several advantages like greener synthetic approach, good to excellent
yield (82-91%), cost-effectiveness, easy work-up and atom-economic procedure.
