Title:Sestrins: A New Kid for Stroke Treatment?
Volume: 14
Issue: 6
Author(s): Xudan Shi, Liang Xu, Jay Malagult, Jiping Tang, Min Yan and John H. Zhang*
Affiliation:
- Department of Anesthesiology, Loma Linda University School of Medicine, 11041 Campus Street, Risley Hall, Room 219, Loma Linda, CA, 92354,United States
Keywords:
AMP-dependent protein kinase, mammalian target of rapamycin, reactive oxygen species, redox, Sestrins.
Abstract: Background: The sestrin family includes several conserved stress-induced proteins that contribute
to the maintenance of homeostasis, DNA stability and cell viability in response to various types
of injuries.
Objective: It is well established that the protective functions of AMP-dependent protein kinase
(AMPK) and/or mammalian target of rapamycin (mTOR) are regulated by sestrins. Additionally, it has
been revealed that sestrins are able to protect cells from oxidative stress by scavenging reactive oxygen
species (ROS).
Method: The essential involvement of sestrins in mTORC1 inhibition and ROS scavenging signaling
pathways, which modulate metabolism homeostasis and regulate autophagy, indicates that sestrins may
serve as a potential agent for cell growth, development, metabolism, and neurodegenerative disorders.
However, the potential role of sestrins in stroke has not been discussed and summarized.
Results & Conclusion: Based on the current understanding of sestrins, it is believed that sestrins are one
of the potential endogenous protective molecules/mechanisms following cerebral stroke, which are associated
with neuronal protection, neuroinflammation suppression, and blood brain barrier preservation.
