Title:Peculiarities of the Clinical Course of Oxidative Protein and Lipid Modification in Children with Acute Rheumatic Fever
Volume: 16
Issue: 4
Author(s): Bibigul Tukbekova, Sandugash Dyussenova, Saule Kizatova, Tattigul Kenzhetayeva, Karlygash Zhubanysheva, Kulziya Zhaktayeva, Saida Sadvakassova, Gulmira Serikova, Nazym Yerimbetova and Aiman Issayeva
Affiliation:
Keywords:
Antioxidant, children, lipid peroxidation, pediatrics, protein modification.
Abstract: Background: Measuring indicators of oxidative protein and lipid metabolism is a diagnostic
criterion of oxidative metabolism disruption at the early stages of chronic somatic pathology formation.
Purpose was to assess the status of protein and lipid oxidative metabolism as a pathogenic link of acute
rheumatic fever by measuring markers of early lesion.
Methods: Research included measurement of lipid peroxidation products and efficiency of antioxidant
protection.
Results: It revealed unidirectional changes that confirm significant cellular membrane lesion. Determined
changes correlated with the activity level of the pathological process while comparing the indicators of ill
children in remission and during exacerbation. It was found that despite the active traditional treatment in
hospitals for in-patients, a number of studied indicators did not return to normal in remission. This shows
the persistence of membrane destruction processes in the body, which supports the pathological process
and requires an investigation of the lesion severity at the level of cell metabolism.
Conclusion: Determination of disruption in the oxidative metabolism system of lipids and proteins, and
the presence of mitochondrial insufficiency signs are universal pathogenic mechanism that reflects the
multifactorial nature of the lesion with acute rheumatic fever.
