Title:The Sustained Effects on Tear Volume of Pilocarpine Hydrochloride in Gelatin by Hydrogel Administered by An Implant-mediated Drug Delivery System
Volume: 14
Issue: 4
Author(s): Seunghee Cha, Hong-Kyun Kim, Hong-Seop Kho and Young-Seok Park*
Affiliation:
- Department of Oral Anatomy, Seoul National University School of Dentistry, P.O. Box: 03080, Seoul,Korea
Keywords:
Dry eye, hydrogel, implant-mediated drug delivery system, osseogate, pilocarpine hydrochloride, sustained release.
Abstract: Background: Pilocarpine hydrochloride is commonly prescribed to patients with dry mouth
and eye using a frequent dosing schedule. The aim of this study was to evaluate the sustained effects of
this highly soluble drug carried by a gelatin hydrogel, which was administered by an implant mediated
drug delivery system (IMDDS).
Methods: The IMDDS was installed in a total of 24 rabbits. After complete healing, pilocarpine hydrochloride
was administered as 30 mg as raw powder (Group 1; n = 8), 30 mg in gelatin hydrogel (Group 2;
n = 8), and 60 mg in gelatin hydrogel (Group 3; n = 8). The effects were evaluated by tear volume
measured using the Schirmer tear test for 2 weeks after administration.
Results: All 3 groups showed an increase in tear volume from the initial measurement at 1 hour. Group
1 exhibited this increase for 24 hours, while Groups 2 and 3 sustained this increase for 5 days and 7.5
days, respectively.
Conclusion: When provided in gelatin hydrogel, highly water-soluble pilocarpine hydrochloride administered
through IMDDS resulted in sustained effects with increased tear volume in normal rabbits.
