Title:FLT3 Inhibitors in the Management of Acute Myeloid Leukemia
Volume: 17
Issue: 8
Author(s): E. Zappone*, M. Defina, L. Aprile, G. Bartalucci, A. Gozzetti and M. Bocchia
Affiliation:
- UOC di Ematologia, Policlinico Le Scotte, AOUS - Siena,Italy
Keywords:
Acute myeloid leukemia, FLT3, inhibitors, molecular target, prognosis.
Abstract: In recent years there has been a great improvement in molecular characterization of acute myeloid
leukemia (AML) allowing the stratification of patients in different rate of risk. Patients with FLT3 mutated AML
have poor prognosis because of resistance to induction chemotherapy or early relapse. Several first and second
generation molecules, able to inhibit FLT3 signaling have been developed and many single agent or combination
studies are ongoing. Of these, quizartinib seems to have the best clinical activity. Unfortunately, resistance to
FLT3 inhibitors has been observed and many scientists are currently investigating new strategy to restore
sensitivity to FLT3 inhibitors.
