Title:Multiple Targets for the Management of Alzheimer’s Disease
Volume: 15
Issue: 10
Author(s): Syed Sayeed Ahmad, Salman Akhtar, Qazi Mohammad Sajid Jamal, Syed Mohd. Danish Rizvi, Mohammad A. Kamal, M. Kalim A. Khan and Mohd. Haris Siddiqui
Affiliation:
Keywords:
Alzheimer's disease, AChE, beta-secretase, beta amyloid.
Abstract: AD is a progressive and irreversible neurodegenerative disease and the
most common cause of dementia in the elderly population. Βeta- amyloid cascade
formation along with several cytoskeleton abnormalities succeeding to the
hyperphosphorylation of microtubule-associated tau protein in neurons leads to the
elicitation of several neurotoxic incidents. As an outcome of these phenomena,
steady growth of dementia in aged population is becoming ubiquitous in both
developed and developing countries. Thus, the key aspiration is to endow with stable
daily life functionality to the person suffering from dementia and to cut down or
slower the symptoms of disease leading to disruptive behavior. In sight of this, the
proteins amyloid-beta, BACE-1, RAGE and AChE are being aimed for the treatment
of AD successfully. Currently, there are several medicines for the treatment of AD under survey like
Galangin, Cymserine, Tolserine, Bisnorcymserine and Huperzine A. The article emphasizes clinical and
neurobiological aspects of AD. The purpose of this review article is to provide a brief introduction of
AD along with the related concept of beta-secretase, beta amyloid and neurotransmitter in the
progression of disease. In the present review, we summarize the available evidence on the new
therapeutic approaches that target amyloid and neurotransmitter in the AD.
