Title:The Role of PPARs in Pathological Cardiac Hypertrophy and Heart Failure
Volume: 23
Issue: 11
Author(s): Hai-Han Liao, Xu-Hui Jia, Huang-Jun Liu, Zheng Yang and Qi-Zhu Tang*
Affiliation:
- Department of Cardiology, Renmin Hospital of Wuhan University; Cardiovascular Research Institute, Wuhan University at Jiefang Road 238, Wuhan 430060,China
Keywords:
Peroxisome proliferator-activated receptors, PPARs, cardiac hypertrophy, heart failure.
Abstract: Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors involved
in the regulation of lipid metabolism, energy production, and inflammation. It is well established that all of the
three isoforms of PPARs expressed in the cardiomyocytes, and that PPARs are closely involved in the regulation
of lipid metabolism and energy homeostasis as well as many other different aspects in the heart. We think that
PPARs are very important therapeutic targets for drug development, however, the drugs targeting at PPARs meet
some trouble in clinical practice, especially the reported side effects related to heart failure. This review summarizes
different functions and mechanisms of each isoform in cardiac hypertrophy and heart failure, for the reason
that if more efforts are made to investigate the interactions among different isoforms, minimize the off-target
effects, and avoid PPARs-independent side effects, we can develop safer and more effective PPAR agonists for
the clinical practice in the near future.
