Title:Hybrid Compounds as Multitarget Directed Anticancer Agents
Volume: 17
Issue: 8
Author(s): Ertan Kucuksayan and Tomris Ozben
Affiliation:
Keywords:
Hybrid Compounds, Cancer, Anticancer Agents, Multitarget Compounds, Drug Design, Natural Products.
Abstract: Cancer is a multifactorial disease including interactions of complex genetic and environmental
factors. Clinical efficacy of anticancer chemotherapies is hampered by various factors including
multidrug resistance (MDR). There is a strong need to discover more potent novel cancer drugs to
kill cancer cells selectively. The recent new strategy for cancer treatment involves the design and synthesis
of hybrid compounds as multitargeted anticancer agents. In this review, we focus on studies
using hybrid compounds which were designed and synthesized from two or more different bioactive
moieties conjugating them into a single hybrid drug. Hybrid compounds having more than a single
target have been considered as more efficient and potent anticancer agents, since it is almost impossible
to destroy cancer cells with a single target. Hybrid compounds overcome many disadvantages of
single cancer drugs such as low solubility, adverse effects, and multi drug resistance. We have compiled
the data of recent studies using the new hybrid anticancer drugs in cancer treatment. Thus, the
design, synthesis and clinical trials of new hybrid compounds should be continued and supported in
future. Results of recent studies have proved that they have a great potential to be used as novel anticancer
drugs.
