Title:Hybrid Drugs as Potential Combatants Against Drug-Resistant Microbes: A Review
Volume: 17
Issue: 8
Author(s): Haythem A. Saadeh and Mohammad S. Mubarak
Affiliation:
Keywords:
Drug resistant, Hybrids, Bacteria, Malaria, Staphylococcus, Tuberculosis
Abstract: Antimicrobial resistance to drugs is a serious threat to public health. Different strategies have
been adopted to deal with antimicrobial resistance to known drugs, one such strategy is the use of drug
hybrids; this is a promising strategy to address the growing problem of drug resistance. The present review
covers the very recent examples of combining (hybrid) two standard drugs in a single molecule
for combating antibiotic-resistant microorganisms, and to present evidence supporting that drug hybrids
are the urgent and practical solution to stop or slow down the spread of drug resistance. In addition, this
review provides a literature overview of antimicrobial hybrids of standard drugs and their impact on antimicrobial
resistance, covering publications between 2015 and 2016.
