Title:Overview of Systems Biology and Omics Technologies
Volume: 23
Issue: 37
Author(s): Bensu Karahalil
Affiliation:
Keywords:
Systems biology, omics technologies, genomics, transcriptomics, proteomics, metabolomics.
Abstract: Traditional technologies using reductionist approach are relatively insufficient to
solve problems in a biological system. Rather than a reductionist approach, systems biology
uses a holistic and integrative approach to better figure out the whole process. Both qualitatively
and quantitatively of biological system provide information about diseases, toxicities,
therapies etc. Omics technologies, which systems biology brings, are valuable tools for
comprehensive analyses. Automated DNA sequencers enabled the sequencing of genomes;
microarray and mass spectrometry analysis permit global transcriptional profiling and lead
to large-scale proteomic and metabolomics analysis. These high-throughput data need to be
interpreted by bioinformatics. So far there has been no concrete published paper that compiles
omics technologies according to PubMed database. In the present review, it was aimed
to give brief description of systems biology and information on the advantages and disadvantages
of omics technologies.
