Title:The Roles of miR-25 and its Targeted Genes in Development of Human Cancer
Volume: 5
Issue: 2
Author(s): Carmen Caiazza and Massimo Mallardo
Affiliation:
Keywords:
Cancer, miR-25, gene expression, oncogenic miRNA, oncosuppressor miRNA, proliferation.
Abstract: microRNAs (miRNAs) are small noncoding RNAs able to suppress gene
expression by targeting messenger RNAs for translational repression or, at lesser extent,
degradation. miRNAs are widely expressed in tissues and organs and play fundamental
roles in controlling cell proliferation, apoptosis, differentiation, cell migration,
autophagy and metabolism. Uncontrolled expression of miRNAs has been associated
with cancer progression, and miRNA up- or down-regulation has been
linked to oncogenic and tumor-suppressive roles in cancers such as breast cancer,
colorectal cancer, lung cancer, gastric cancer and glioblastoma. Altered expression
of the miRNA mir-25 has been reported in many human malignant tumors, participating
in various cellular processes accordingly with its broad range of potential
mRNAs target. In the present review, we briefly discuss the mechanisms underlying miR-25-mediated
tumorigenesis in six different human cancers and its possible future as a potential diagnostic and prognostic
parameter as well as therapeutic target in clinical applications.
