Title:Therapeutic Potential of Targeting TREM-1 in Inflammatory Diseases and Cancer
Volume: 22
Issue: 41
Author(s): Maria Carla Bosco, Federica Raggi and Luigi Varesio
Affiliation:
Keywords:
Innate immune cells, immunoregulatory receptors, triggering receptor expressed on myeloid cells, inflammation, inflammatory
diseases, cancer, disease models, therapy.
Abstract: The triggering receptor expressed on myeloid cells (TREM)-1 is a member of the
Ig-like immunoregulatory receptor family and a major amplifier of innate immune responses.
TREM- 1 has been implicated in the development and perpetuation of a number of
inflammatory disorders, and soluble TREM-1 levels are a clinically valuable diagnostic and
prognostic biomarker in patients with sepsis and other types of acute and chronic inflammation-
associated diseases, easily detectable in biological fluids. High TREM-1 expression in
macrophages infiltrating human tumors and increased concentrations of soluble TREM-1
also correlate with aggressive tumor behavior and recurrence and are a relevant independent
predictor of poor patient survival. Pharmacological inhibition of TREM-1 has proven effective
in preclinical mouse models of infectious and non-infectious inflammatory disorders
and malignancies, conferring survival advantages and protecting from organ damage or
tumor growth by attenuating inflammatory responses. This review aims at providing a comprehensive
overview of the state of the art on TREM-1 research. We review the literature addressing TREM-1
role in the amplification of myeloid cell inflammatory responses at pathologic sites and its relevance in the development,
severity, and progression of inflammatory diseases and cancer. Furthermore, we discuss recent advances
in the pharmacological use of TREM-1 inhibitors in mouse preclinical models, emphasizing their potential in new
strategies for the treatment of acute and chronic inflammatory conditions and for therapeutic intervention in cancer.
This information will be of value to investigators in the field of pharmacology, drawing attention to novel
therapeutic opportunities to complement current treatment approaches.
