Title:Heterocyclic Compounds: Effective α-Amylase and α-Glucosidase Inhibitors
Volume: 17
Issue: 4
Author(s): Mina Saeedi, Abbas Hadjiakhondi, Seyed Mohammad Nabavi and Azadeh Manayi
Affiliation:
Keywords:
α-Amylase, α-Glucosidase, Diabetes, Heterocycles, Synthesis, Natural Products.
Abstract: Diabetes Mellitus (DM) is a metabolic disease characterized by high blood sugar levels. Recently,
it has emerged as an important and global health problem with long-term complications and
high economic burden. α-Amylase (α-Amy) and α-glucosidase (α-Gls) are two enzymes which are involved
in the hydrolysis of starch into sugars and disaccharides leading to the increase of blood glucose
level. Hence, inhibition of α-amylase and α-glucosidase plays key role in the treatment of type 2 diabetes.
Heterocyclic compounds -both synthetic and naturally occurring derivatives- possess efficient biological
properties. At this juncture, they have demonstrated potent inhibitory activity against α-Amy
and α-Gls and were found to be versatile tools for the development of novel anti-diabetic agents.
