Title:Developing Antitumor Magnetic Hyperthermia: Principles, Materials and Devices
Volume: 11
Issue: 4
Author(s): Alexander M. Tishin, Alexander A. Shtil, Alexander P. Pyatakov and Vladimir I. Zverev
Affiliation:
Keywords:
Hyperthermia, magnetic nanoparticles, therapeutic combinations, treatment, tumors.
Abstract: Background and Objective: Methods of local or loco-regional anticancer
treatment are of the utmost importance because the therapeutic ‘power’ is applied
directly to the disease site. Consequently, general toxicity is minimized. Hyperthermia,
that is, a sustained increase of intratumoral temperature up to 45oC, has been
investigated as a perspective treatment modality alone and/or in combination with
ionizing radiation or chemotherapy. Still, the surrounding tissues can be damaged by
the external heat.
Method: Development of new materials and devices gave rise to methods of inducing
hyperthermia by a high frequency magnetic or electromagnetic field applied to the
tumor with exogenous nanosized particles captured within it. The idea of this approach
is the release of local heat in the vicinity of the magnetic nanoparticle in a time-varying magnetic
field due to transfer of external magnetic field energy into the heat. Therefore, tumor cells are heated
whereas the peritumoral non-malignant tissues are spared.
Results: This review analyzes recent advances in understanding physical principles that underlie magnetic
hyperthermia as well as novel approaches to obtain nanoparticles with optimized physico-chemical, toxicological
and tumoricidal properties. Special focus is made on the construction of devices for therapeutic
purposes.
Conclusion: The review covers recent patents and general literature sources regarding magnetic hyperthermia,
the developing approach to treat otherwise intractable malignancies.
