Title:Spirooxindoles as Potential Pharmacophores
Volume: 17
Issue: 16
Author(s): Siva S. Panda*, Rachel A. Jones, Praveen Bachawala and Prabhu P. Mohapatra
Affiliation:
- Department of Chemistry & Physics, Augusta University, Augusta, GA 30912,United States
Keywords:
Biological importance, chemistry, heterocycles, pharmacophores, spirooxindoles, synthesis.
Abstract: Objective: The spirooxindole heterocyclic scaffold is found in many natural products and
has been identified as an important bioactive agent.
Background: Over the past few decades, various spirooxindole-containing compounds have been
reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.
This mini-review describes the most promising examples of this class of compounds possessing
biological activity including anticancer, anti-inflammatory, and antimicrobial activities.
Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole
scaffold.
