Title:Pharmacological Properties and Therapeutic Potential of Naringenin: A Citrus Flavonoid of Pharmaceutical Promise
Volume: 22
Issue: 28
Author(s): Neha Rani, Saurabh Bharti, Bhaskar Krishnamurthy, Jagriti Bhatia, Charu Sharma, Mohammad Amjad Kamal, Shreesh Ojha and Dharamvir Singh Arya
Affiliation:
Keywords:
Naringenin, animals, drug design, antioxidant, anti-inflammatory, phytochemicals, natural compounds, cancer.
Abstract: Naringenin chemically known as 5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one is a common dietary polyphenolic constituent of the citrus fruits. It has received considerable
attention for pharmaceutical and nutritional development due to potent pharmacological
activities and therapeutic potential. Accruing evidence from both in vitro and in
vivo studies have unraveled numerous biological targets along with complex underlying
mechanisms suggesting possible therapeutic applications of naringenin in various neurological,
cardiovascular, gastrointestinal, rheumatological, metabolic and malignant disorders.
Functionally, this ameliorative effect of naringenin is primarily attributed to its antiinflammatory
(via inhibiting recruitment of cytokines and inflammatory transcription factors)
and anti-oxidant (via scavenging of free radicals, bolstering of endogenous antioxidant
defense system and metal ion chelation) effects. The present article provides a
comprehensive review of the various studies that have evaluated the therapeutic potential of
naringenin and its actions at the molecular level. It also summarizes the pharmacokinetic data and issues and
challenges involved in pharmaceutical development and suggest that it may be a potential agent for further exploration
as well as may be useful as a dietary adjunct in treatment of various human ailments.
