Title:Biodegradable Polymeric Nanoparticles as the Delivery Carrier for Drug
Volume: 13
Issue: 4
Author(s): Kai Zhao, Dan Li, Ci Shi, Xueling Ma, Guangu Rong, Hong Kang, Xiaohua Wang and Bin Sun
Affiliation:
Keywords:
Chitosan, commercialization, drug delivery, nanotechnology, polymeric nanoparticles, synthesis methods.
Abstract: Background: Drug research and development has entered into the new epoch of innovation
formulation, and the drug delivery system has been in the forefront of pharmaceutical innovation.
Nanotechnology is widely used in fiber and textiles, electronics, space, agriculture, forensic science
and medical therapeutics. It increasingly plays a significant role in drug delivery system. Compared
with traditional delivery system, the nanoparticle drug delivery system has lots of merits, such as the high drug loading
ability, the excellent biocompatibility, low toxicity, controlled and targeted drug release.
Methods: We undertook a structured research of biodegradable polymeric nanoparticles used as delivery carrier for drug
using a focused review question and inclusion/exclusion criteria. We have searched the bibliographic databases for peerreviewed
research literature. The outstanding characteristics of the screened papers were described respectively, and a systematic
content analysis methodology was used to analysis the findings.
Results: Seventy-three papers were included in the review, the majority defined leadership and governance approaches
that had impacted upon the polymeric nanoparticles as the delivery carrier for drug in therapeutic applications and developments.
Seven papers outlined the superiority characteristics of polymeric nanoparticles that applied in the field of vaccine.
Forty-seven papers overviewed the application prospects of polymeric nanoparticles used as drug delivery carrier for
cancer. These included current advances in research and clinical applications of polymeric nanoparticles. The review identified
the drug delivery carrier of biodegradable polymeric nanoparticles, and we described the synthesis methods, applications
and challenges of polymeric nanoparticles.
Conclusion: The findings of this review identified that the biodegradable polymeric nanoparticles were used as delivery
carrier for drug currently. It also indicates that the biodegradable polymeric nanoparticles play an important role in the
drug delivery.
