Title:The use of Azoles Containing Natural Products in Cancer Prevention and Treatment: An Overview
Volume: 18
Issue: 1
Author(s): Nasimudeen R. Jabir, Chelapram K. Firoz, Ashish Bhushan, Shams Tabrez*Mohammad A. Kamal*
Affiliation:
- King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589,Saudi Arabia
- King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80216, Jeddah 21589,Saudi Arabia
Keywords:
Alkaloids, azoles, cancer treatment, carbazoles, natural products, oxazoles, thiazoles.
Abstract: Background & Objective: Cancer is one of the leading causes of death worldwide. In view of ever
increasing number associated with cancer related death, there is an urgent need to find out a novel compound
especially of natural origin (better efficacy, less or non-toxic and cost effective) that could serve against the treatment
of all forms of cancer. Currently, available treatment options related to cancer have their certain limitations especially
in the case of solid tumors.
Method: In search of the natural anticancer compound, alkaloids, in general, have been exploited by the scientist
working in this field of research. Among these alkaloids, azoles (secondary metabolite) have been significantly
highlighted in literature because of their anticancer potential and better efficacy against various forms of cancer.
Results: Their mechanism of action includes induction in the cleavage of poly-ADP ribose polymerase (PARP),
induction of caspase 3 and caspase 9, modulation of nuclear factor kappa B, damage to DNA, cell cycle arrest at G1
and G2/M stage, apoptosis and c-Myb inhibition. In the current article, we have tried to cover various azoles especially
from oxazoles, thiazoles and carbazoles class that have been reported for their anticancer potential.
Conclusion: Based on our article, we believe that, soon, the scientific community will come up with certain azole
which will work against cancer at large rather than a specific type of cancer.
