Title:Systematic Evaluation of Drug-Loaded Hydrogels for Application in Osteosarcoma Treatment
Volume: 17
Issue: 10
Author(s): Seyit Ali Gumustas, Mehmet Isyar, Savas Topuk, Ibrahim Yilmaz, Kadir Oznam, Tolga Onay, Onder Ofluoglu and Mahir Mahirogullari
Affiliation:
Keywords:
Controlled release, drug delivery systems, hydrogel, steosarcoma treatment.
Abstract: This is a literature review of studies focusing on the preparation of hydrogels for use as oncological drug delivery
systems in the treatment of osteosarcoma (OS). The databases of the US National Library of Medicine National Institutes
of Health, Embase, OVID, and Cochrane Library, and the references of retrieved studies, were traced from 1843 to
December 21, 2015, without language restrictions. The obtained data were evaluated by complementary statistical methods.
Potentially relevant studies were found and included in the analysis. OS-specific chemotherapeutic agents can be successfully
embedded within the hydrogels and these drug-loaded hydrogels can be applied locally, rather than systemically,
without organ tissue toxicity. Further, OS-specific drug-loaded hydrogels significantly increased tumor inhibition and decreased
osteolysis and lung metastases. Drug-loaded hydrogels could be useful in the treatment of OS, although their development
remains at the experimental phase. Following evaluation of their application in surgery and the completion of
drug release kinetics studies, drug-loaded hydrogels could be tested on living mammals in large samples with the aim of
applying these in clinical settings. In the future, development of such drug delivery systems and application of targeted
approaches against osteosarcoma and other malignancies may render surgery, radiotherapy and chemotherapy unnecessary.
