Title:Cell Cycle Kinases in Osteosarcoma: Potential for Therapeutic Intervention
Volume: 22
Issue: 31
Author(s): Li Cheng, Chongchong Wang and Juehua Jing
Affiliation:
Keywords:
Checkpoint kinase inhibitors, cyclin-dependent kinase inhibitors, polo-like kinase inhibitors, aurora kinase inhibitors, cell cycle,
osteosarcoma.
Abstract: Osteosarcoma is the most common type of primary bone tumor in adolescents
and young adults. The dysregulation of cell cycle control and cell division often results in
the aberrant growth of osteosarcoma cells. The primary proteins involved in cell cycle control
and cell division include checkpoint kinases (CHKs), cyclin-dependent kinases (CDKs),
polo-like kinases (PLKs) and aurora kinases (AURKs). In recent years, a large number of
these protein kinase inhibitors have been identified in osteosarcoma. In this review, we highlight
the current drugs being developed to target these protein kinases in osteosarcoma.
