Title:Clinical Studies Using Biological and Synthetic Materials for Meniscus Replacement
Volume: 12
Issue: 4
Author(s): David D Lin, Natasha E. Picardo*, Adetola Adesida and Wasim S Khan
Affiliation:
- Royal London Hospital, Whitechapel Road, London E1 1BB,United Kingdom
Keywords:
Meniscal replacement, meniscectomy, tissue engineering, meniscal substitute, biological material, meniscal injury.
Abstract: Meniscal injury is a common problem among sportsmen and increasingly seen in the older and
more active population. The traditional treatment options include a partial meniscectomy, which provides
good mechanical and pain relief to the patient. However, the focus of treatment is shifting towards repairing
meniscal tears where possible and replacement of the lost meniscal tissue where appropriate. Replacement
can be total or partial. Total meniscal replacement using an allograft, is usually reserved for
young patients, who meet certain criteria and who have undergone several subtotal meniscectomies or a
single stage total meniscectomy and are still symptomatic. Partial meniscal replacement can be utilized in
conjunction with a partial meniscectomy to fill the resulting space left by the resection. Collagen based
implants and synthetic scaffolds have entered the European market but have demonstrated mixed results
in clinical trials. Tissue engineering to create an implant that mimics the biomechanical properties holds
much potential for future research.
