Title:The Importance of Melatonin and Mitochondria Interaction in Mood Disorders and Schizophrenia: A Current Assessment
Volume: 23
Issue: 20
Author(s): Abdülhadi Cihangir Uguz, Kadir Demirci and Javier Espino
Affiliation:
Keywords:
Bipolar disorder, Calcium signaling, Depression, Mitochondria, Mood disorder, Oxidative stress,
Schizophrenia.
Abstract: Mitochondria play a critical role in regulating cellular functions,
such as redox signaling, calcium homeostasis, and apoptosis. Also,
mitochondria are crucial for neurogenesis and neuronal functions.
Melatonin is an indole analog hormone, which is generally produced by the
pineal gland. It plays a vital role in circadian rhythm and act as a powerful
antioxidant by scavenging free radicals, immunomodulators, and anticancer
agents. Schizophrenia and mood disorders are the two major psychiatric
disorders. Disturbances of sleep and circadian rhythms are well-known
symptoms of schizophrenia and mood disorders (bipolar disorder, major
depression). Since melatonin has a regulator effect on circadian rhythm and
sleep quality, it has a close interaction with schizophrenia and mood
disorders. Herein, we aimed to summarize the effects of melatonin on
mitochondrial activity in schizophrenia and mood disorders.
