Title:Acethylcholinesterase Inhibition, Antibacterial and Antioxidant Properties of Diaryl Oxalates
Volume: 13
Issue: 1
Author(s): Gunay K. Kantar, Nimet Baltaş*, Fatih Ş. Beriş and Selami Şaşmaz
Affiliation:
- Recep Tayyip Erdogan University, Science and Art faculty, Chemistry Department, Rize, 53100,Turkey
Keywords:
Anti-acetylcholinesterase, antimicrobial, antioxidant, diaryl oxalate.
Abstract: Objective: The main study was to synthesize the diaryl oxalates containing
pharmacophore groups like eugenol and guaiacol moieties, investigate antioxidant,
antibacterial and acethylcholinesterase inhibitory properties and compare with
each other.
Method: The compounds were screened for their antioxidant properties by
employing three in vitro assays like CUPric Reducing Antioxidant Capacity
(CUPRAC) and 2,2-Diphenyl-1-Picrylhydrazyl (DPPH•) radical scavenging assay,
2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS•+) assay and they exhibited
very promising results. Also, The compounds were evaluated for their antiacetylcholinesterase
activity (anti-AChE) and anti-microbial effects against Bacillus
subtilis ATCC 6633, S. pyogenes ATCC 19615, Y. pseudotuberculosis ATCC 911, E. cloaceae ATCC
25923, and E. coli ATCC 25922.
Results: The compounds were found to possess good antioxidant (TEAC values:7.834-9.353 mM
TEAC/mg compound) and inhibitiory activity against AChE (IC50=11.95±0.27 for compound 2). Antimicrobial
activity results show that compound 1 has the same antimicrobial effect on the bacteria in
this study and is more effective than compound 2.
Conclusion: The results indicate that these compounds have not only good antioxidant and antimicrobial
activity, but is also a powerful AChE inhibitors.
