Title:Specific Targeting of Akt Kinase Isoforms: Taking the Precise Path for Prevention and Treatment of Cancer
Volume: 18
Issue: 4
Author(s): Nand Kishor Roy, Devivasha Bordoloi, Javadi Monisha, Ganesan Padmavathi, Jibon Kotoky, Ramesh Golla and Ajaikumar B. Kunnumakkara
Affiliation:
Keywords:
Akt1, Akt2, Akt3, cancer, targets, biomarkers.
Abstract: Akt kinase is a serine threonine kinase that exists in three isoforms, located in different
chromosomes and has distinct sites of expression which orchestrates diverse cellular processes required
for normal functioning of the cell. Though, these Akt isoforms have some overlapping actions, but they
also have specific roles and interestingly, sometimes they even perform contrasting functions. There are
various alterations such as amplification, overexpression, mutation, etc. associated with these isoforms
which have great implications in the development of cancer. Moreover, these alterations also induce
chemo and radio resistance in cancer cells that impede the existing treatment modules. Furthermore,
many reports have shown their potential as efficient prognostic biomarkers. Although, many studies
have discussed the implications of Akt kinase proteins in different cancers but in-depth analysis of isoform-
specific involvement is least examined and hence demands more attention. This review discusses
the divergent roles of Akt isoforms comprehensively in different cancers and finding their immense
prospects as potential targets for cancer prevention and treatment.
