Title:The Potential Application of Biomaterials in Cardiac Stem Cell Therapy
Volume: 23
Issue: 6
Author(s): Raja Ghazanfar Ali Sahito, Poornima Sureshkumar, Isaia Sotiriadou, Sureshkumar Perumal Srinivasan, Davood Sabour, Jürgen Hescheler, Kurt Pfannkuche and Agapios Sachinidis
Affiliation:
Keywords:
Scaffold biomaterials, polymers, stem cells, tissue engineering, regenerative medicine, therapeutics.
Abstract: Biomaterials play a vital role in the field of regenerative medicine and tissue
engineering. To date, a large number of biomaterials have been used in cardiovascular
research and application. Recently, biomaterials have held a lot of promise in cardiac stem
cell therapy. They are used in cardiac tissue engineering to form scaffolds for cellular
transplantation, promote angiogenesis, enhance transplanted cell engraftment or influence
cell migration. The science of biomaterial designing has evolved to an extent where they can
be designed to mimic the microenvironment of a cardiac tissue in vivo and contribute in deciding the fate of
transplanted stem cells and induce cardiac lineage oriented stem cell differentiation. In this review, we focus
on biomaterials used in cardiovascular stem cell research, tissue engineering and regenerative medicine and
conclude with an outlook on future impacts of biomaterial in medical sciences.
