Title:Nanoparticulate Drug Delivery to Colorectal Cancer: Formulation Strategies and Surface Engineering
Volume: 22
Issue: 19
Author(s): Thao Truong-Dinh Tran, Phuong Ha-Lien Tran, Yichao Wang, Puwang Li and Lingxue Kong
Affiliation:
Keywords:
Nanoparticles, poly (lactide-co-glycolide), chitosan, colorectal cancer, theranostic, surface engineering.
Abstract: The evolution of polymer-based nanoparticle as a drug delivery carrier has greatly contributed to the development
of advanced nano and micro-medicine in the past few decades. The polymer-based nanoparticles of biodegradable
and biocompatible polymers such as poly (lactide-co-glycolide) and chitosan which have been approved
by Food & Drug Administration and/or European Medicine Agency can particularly facilitate the maintaining
of specific properties for a real transition from laboratory to the clinical oral and parental administration. This
review presents an overview of the strategies of preparing polymeric nanoparticles and using them for targeting colorectal
cancer. Theranostics and surface engineering aspects of nanoparticle design in colonic cancer delivery are
also highlighted.
