Title:Mutations of Chromatin Structure Regulating Genes in Human Malignancies
Volume: 17
Issue: 5
Author(s): Jian Chen, Franklin H. Herlong, John R. Stroehlein and Lopa Mishra
Affiliation:
Keywords:
Somatic mutation, Cancer, Chromatin structure, Chromatin remodeling, Chromatin modification, TCGA.
Abstract: Chromatin structure regulating processes mediated by the adenosine triphosphate (ATP) –
dependent chromatin remodeling complex and the covalent histone-modifying complexes are critical
to gene transcriptional control and normal cellular processes, including cell stemness, differentiation,
and proliferation. Gene mutations, structural abnormalities, and epigenetic modifications that lead to
aberrant expression of chromatin structure regulating members have been observed in most of human
malignancies. Advances in next-generation sequencing (NGS) technologies in recent years have allowed
in-depth study of somatic mutations in human cancer samples. The Cancer Genome Atlas
(TCGA) is the largest effort to date to characterize cancer genome using NGS technology. In this review, we summarize
somatic mutations of chromatin-structure regulating genes from TCGA publications and other cancer genome studies,
providing an overview of genomic alterations of chromatin regulating genes in human malignancies.
