Title:Neuroprotective Role of Nanoparticles Against Alzheimer's Disease
Volume: 17
Issue: 2
Author(s): Magisetty Obulesu and Magisetty Jhansilakshmi
Affiliation:
Keywords:
Alzheimer’s disease, curcumin, metal chelators, Redox nanoparticles.
Abstract: Background: Alzheimer's disease (AD) is a devastative neurodegenerative disorder with a complex etiology.
Despite numerous novel nanotechnology methods targeted against cancer and neurodegenerative diseases
such as AD in the past decade, several challenges impeded their success.
Objective: We ventured to circumvent these challenges by synthesizing redox nanoparticles (RNP) such as Nitroxide
radical, 2,2,6,6 tetramethylpiperidinyl-N-oxyl (TEMPO). Piperine in association with RNP successfully scavenges
reactive oxygen species (ROS). Our studies have also shown that the piperine associated with RNP confers
enhanced protection against AD in vitro.
Conclusion: This review summarizes our recent findings on the protective roles of redox nanoparticles both
in vitro and in vivo. In addition, vital role of nanoparticles employed to encapsulate natural compounds such as curcumin and metal
chelators has been summarized. We warrant further studies in animal models using these protective nanoparticles.
