Title:Nutraceuticals against Neurodegeneration: A Mechanistic Insight
Volume: 14
Issue: 6
Author(s): Vivekkumar P. Dadhania, Priyanka P. Trivedi, Ajit Vikram and Durga Nand Tripathi
Affiliation:
Keywords:
Neurodegeneration, mitochondria, calcium, oxidative stress, inflammation, nutraceuticals.
Abstract: The mechanisms underlying neurodegenerative disorders are complex and
multifactorial; however, accumulating evidences suggest few common shared pathways.
These common pathways include mitochondrial dysfunction, intracellular Ca2+ overload, oxidative stress and inflammation.
Often multiple pathways co-exist, and therefore limit the benefits of therapeutic interventions. Nutraceuticals have
recently gained importance owing to their multifaceted effects. These food-based approaches are believed to target
multiple pathways in a slow but more physiological manner without causing severe adverse effects. Available information
strongly supports the notion that apart from preventing the onset of neuronal damage, nutraceuticals can potentially
attenuate the continued progression of neuronal destruction. In this article, we i) review the common pathways involved in
the pathogenesis of the toxicants-induced neurotoxicity and neurodegenerative disorders with special emphasis on
Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), Multiple sclerosis (MS) and Amyotrophic
lateral sclerosis (ALS), and ii) summarize current research advancements on the effects of nutraceuticals against these
detrimental pathways.
