Title:Resolving Inflammation in Heart Failure: Novel Protective Lipid Mediators
Volume: 17
Issue: 10
Author(s): Marta Reina-Couto, Luís Vale, Jorge Carvalho, Paulo Bettencourt, António Albino-Teixeira and Teresa Sousa
Affiliation:
Keywords:
Heart failure, resolution of inflammation, proresolving lipid mediators, cardiovascular/metabolic and renal protection,
therapeutic modulation.
Abstract: Inflammation is an important pathogenic mechanism in chronic heart failure (HF). The perpetuation
of the inflammatory response in this syndrome may result either from excessive activation of proinflammatory
cascades or disturbances in the resolution of inflammation. However, although cardiovascular research has extensively investigated
the proinflammatory processes involved in chronic HF pathophysiology, the mechanisms responsible for inflammation
resolution in this disease remain largely disregarded. The resolving response is currently considered an active
process involving specific effectors that limit the progression of inflammation and promote tissue regeneration. This article
aims at reviewing the major classes of lipid mediators of inflammation resolution, their cardiovascular, metabolic and
renal protective effects that might putatively delay the onset and progression of chronic HF, and their therapeutic modulation.
Furthermore, it also aims to emphasize the importance of adopting therapeutic strategies that stimulate the resolution
of inflammation in chronic HF.
