Title: Novel Paramagnetic Contrast Agents for Molecular Imaging and Targeted Drug Delivery
Volume: 5
Issue: 6
Author(s): Gregory M. Lanza, Patrick Winter, Shelton Caruthers, Anne Schmeider, Kathy Crowder, Anne Morawski, Huiying Zhang, Michael J. Scott and Samuel A. Wickline
Affiliation:
Keywords:
molecular imaging, restenosis, drug delivery, nanoparticle, nanotechnology, magnetic resonance imaging, vascular smooth muscle cells
Abstract: Molecular biology and genomic sciences are revealing the early biological signatures for many diseases. In response, the Molecular Imaging community is rapidly developing contrast agents to visualize the nascent pathological changes and to concomitantly deliver treatment directly to the site of disease. The evaluation, development and use of these new agents require a complementary understanding of contrast chemistry and imaging techniques. The fundamental issues surrounding magnetic contrast agent development, rational drug delivery, MR molecular imaging, and their interdependence are elucidated.
