Title:Quinazolines as Apoptosis Inducers and Inhibitors: A Review of Patent Literature
Volume: 11
Issue: 1
Author(s): Samir Mehndiratta, Sameer Sapra, Gurpreet singh, Manwinder Singh and Kunal Nepali
Affiliation:
Keywords:
Apoptosis inducers, apoptosis inhibitors, cancer, caspases, p53, tubulin, quinazolines.
Abstract: Quinazoline scaffold has been successfully utilized for development of
various inhibitors of tubulin, epidermal growth factor receptor (EGFR), polo like
kinases (PLKs), Hedgehog-Gli signaling pathway and protein kinase B (PKB) /Akt pathway. Compounds based on quinazolines
have shown efficacies in µM to nM range in various cancer cell lines and thus could be useful scaffolds for development
of both apoptosis inducers as well as inhibitors. This compilation is based on various patents published till 2015
and divides the quinazolines in two main categories: Quinazolines as apoptosis inducers and as apoptosis inhibitors. These
two main categories are further sub-categorized based on the use/pharmacological indications for these classes of patented
compounds. This review will act as a tool for the researchers working on exploring the anticancer potential of quinazoline
as a privileged heterocyclic. The promising anticancer profile of some of the quinazoline based compounds clearly highlights
the clinical potential of this heterocycle.
