Title:Targeting Transient Receptor Potential Canonical Channels for Diseases of the Nervous System
Volume: 18
Issue: 12
Author(s): Yibin Wang, Jiyuan Bu, Haitao Shen, Haiying Li, Zhong Wang*Gang Chen
Affiliation:
- Department of Neurosurgery, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006,China
Keywords:
Brain injury, Ca2+, hemorrhagic transformation, intracerebral hemorrhage, nerve system, subarachnoid hemorrhage,
TRPCs.
Abstract: Background: Ca2+ influx plays an essential role in the physiological and pathophysiologic
processes of several nervous system diseases. The transient receptor-potential channels (TRPCs) form
a family of voltage –sensitive calcium ion channels.
Objective: In this review, we will discuss the importance of transient receptor potential canonical
(TRPC) channels, which is a crucial family of calcium channels. This article reviews the role of
TRPC channels in the pathogenesis of diseases such as brain hemorrhage, hemorrhagic transformation
after cerebral infarction, subarachnoid hemorrhage, and brain injury.
Results: TRPC has especially high expression in the central nervous system (CNS), and was involved in
several physiological functions. The TRPC family is associated with cerebral vasospasm after subarachnoid
hemorrhage, neuronal damage after intracerebral hemorrhage, NMDA cytotoxicity in cerebral
ischemia, nervous system tumors, neurodegenerative diseases, neural addiction and other diseases.
Conclusion: The TRPC family has rich functionality and is widely distributed, with different functions
in various nervous system diseases.
