Title:The Yin and Yang of Antiviral Innate Immunity in Central Nervous System
Volume: 22
Issue: 6
Author(s): Ali Zohaib, Adeel Sarfraz, Qari Muhammad Kaleem, Jing Ye, Mudassar Niaz Mughal, Muhammad Tariq Navid, Faheem Ahmed Khan, Xiaodong Duan, Bibo Zhu, Shengfeng Wan and Shengbo Cao
Affiliation:
Keywords:
Central nervous system, innate immunity, PAMPs, PRRs, RLRs, TLRs, virus.
Abstract: The innate immune system provides protection against invading neurotropic viruses. It acts as the first
line of defense against invading viruses and plays an elementary role in their pathogenesis. The list of viruses capable
of infecting human central nervous system (CNS) is quite long, most important of them are Japanese Encephalitis
virus (JEV), rabies virus, West Nile virus (WNV), herpes simplex virus (HSV), St. Louis encephalitis virus
(SLEV), La Crosse virus, tick borne encephalitis virus (TEBE) and polio virus. Germ line pattern recognition receptors (PRRs) such
as Toll like receptors (TLRs), nucleotide binding oligomerization domain (NOD) - like receptors (NLRs), retinoic acid-inducible gene I
(RIG-I) -like helicases or RIG-I-like receptors (RLRs) and cytosolic DNA sensors recognize the pathogen associated molecular patterns
(PAMPs) and initiate an immune response against invading pathogen. Although PRRs were originally characterized in peripheral immune
cells but accumulating evidence also suggest their crucial roles in CNS to combat against neurotropic viruses. In this review, we
will highlight the recent developments in our understating of the mechanisms by which PRRs in resident brain cells provide protection
against invading neurotropic viruses.
