Title:Therapeutic Outlook of Pyrazole Analogs: A Mini Review
Volume: 17
Issue: 11
Author(s): Swastika Ganguly*Sony K. Jacob
Affiliation:
- Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi, Jharkhand-835215,India
Keywords:
Analgesic, antibacterial, anticancer, anti-inflammatory, antipyretic, antiviral, pyrazole.
Abstract: Background: Pyrazole is one of the excellent structural motifs in medicinal chemistry.
Various physiological and therapeutic possibilities have been exploited by incorporating different
pharmacophoric groups in the pyrazole moiety.
Objective: This has opened a new arena of pyrazole analogs that can be developed into medicinal agents
such as anti-inflammatory, analgesic, antipyretic, antiviral, antibacterial, anticancer, anticonvulsant, hypoglycemic,
carbonic anhydrase inhibitors, mono amino oxidase (MAO) inhibitors, etc. Though, pyrazole
analogs have proven their clinical efficacy as different pharmacological agents, a few of them have been
withdrawn from the market due to their side effects. Thus, research on potential new drug candidates
bearing the pyrazole moiety with lesser side effects has fairly increased over the last few years.
Conclusion: This review explores diverse pharmacological activities exhibited by pyrazole analogs reported
recently, which may be of great help for researchers in the area of drug discovery to understand
the current scenario of pyrazole based compounds and to design and develop newer drug candidates
with improved efficacy.
