Title:Chemical Structure Characteristics and Bioactivity of Small Molecule FAK Inhibitors
Volume: 16
Issue: 8
Author(s): Fang-Yuan Cao, Xiao-Ping Zhou, Jing Su, Xiao-Hong Yang, Feng-Hui Mu, Jia-Yi Shen and Wei Sun
Affiliation:
Keywords:
Cancer, chemical structure, FAK inhibitors.
Abstract: Focal adhesion kinase (FAK) is a non-receptor tryosine kinase that plays a vital role in tumor cell survival,
proliferation and migration. It has been shown that inhibiting the activity of FAK may result in impeding tumor cells
invasion and growth. There are several small molecule FAK inhibitors which have been developed with outstanding
FAK inhibitory activity. And most of the small molecules are nitrogen-containing aromatic compounds. This review
describes the chemical structure characteristics and activity of current small molecule FAK inhibitors that aims to
serve as a future reference for the development of potential FAK inhibitors.
