Title:Perspectives in Engineered Mesenchymal Stem/Stromal Cells Based Anti- Cancer Drug Delivery Systems
Volume: 11
Issue: 1
Author(s): Darinka Gjorgieva Ackova, Tatjana Kanjevac, Lia Rimondini and Darko Bosnakovski
Affiliation:
Keywords:
Cancer therapy, cellular therapy, drug delivery, mesenchymal stem cells, oncolytic viruses, pro-drug, target therapy.
Abstract: Understanding and apprehension of the characteristics and circumstances in which mesenchymal
stem cells (MSCs) affect and make alterations (enhance or reduce) to the growth of tumors
and metastasis spread is pivotal, not only for reaching the possibility to employ MSCs as drug delivery
systems, but also for making forward movement in the existing knowledge of involvement of major
factors (tumor microenvironment, soluble signaling molecules, etc.) in the process of carcinogenesis. This capability is reliable
because MSCs present a great basis for engineering and constructions of new systems to target cancers, intended to
secrete therapeutic proteins in the tumor region, or for delivering of oncolytic viruses’ directly at the tumor site (targeted
chemotherapy with enzyme prodrug conversion or induction of tumor cell apoptosis). MSCs as a crucial segment of the
tumor surroundings and their confirmed tumor tropism, are assumed to be an open gateway for the design of promising
drug delivery systems. The presented paper reviews current publications in this fieldwork, searches out the most recent
patents that were published after 2012 (WO2014066122, US20140017787, WO2015100268, US20150086515), and tries
to present the current progress and future prospective on the design and development in anti-cancer drug delivery systems
based on MSCs.
