Title:Perspectives of Benzimidazole Derivatives as Anticancer Agents in the New Era
Volume: 16
Issue: 11
Author(s): Snehlata Yadav, Balasubramanian Narasimhan and Harmeet kaur
Affiliation:
Keywords:
Heterocyclic, benzimidazole, pharmacophore, anticancer, MCF-7.
Abstract: Cancer is one of the deadliest diseases nowadays and is a great topic for research as
the challenging task is to develop new entities with selectivity towards cancerous cells.
Heterocyclic compounds are of great importance in medicinal chemistry as they possess an
extensive range of therapeutic applications. Benzimidazole is one such important heterocyclic
organic compound having structural analogy to nucleotides found in human body and hence is
an important pharmacophore in medicinal chemistry. A variety of marketed drugs containing
benzimidazole are thiabendazole, flubendazole (anthelmintic), astmizole (antihistaminic),
lansoprazole and omeprazole (antiulcerative). In the light of the above facts, this review is an
attempt to summarize the collective contributions from the authors around the world in the field
of anticancer agents. This review highlights synthetic schemes and anticancer activity results of
the research done in the past years.
