Title:siRNA Therapy, Challenges and Underlying Perspectives of Dendrimer as Delivery Vector
Volume: 21
Issue: 31
Author(s): Rakesh Kumar Tekade, Rahul G.S. Maheshwari, Piyoosh A. Sharma, Muktika Tekade and Abhay Singh Chauhan
Affiliation:
Keywords:
Dendrimer, siRNA, nanocarrier, drug delivery, therapy.
Abstract: siRNA technology presents a helpful means of gene silencing in mammalian cells. Advancement in the
field includes enhanced attentiveness in the characterization of target and off-target effects employing suitable controls
and gene expression microarrays. These will permit expansion in the measurement of single and multiple target
combinations and also permit comprehensive efforts to understand mammalian cell processes. Another fact is that the delivery of
siRNA requires the creation of a nanoparticulate vector with controlled structural geometry and surface modalities inside the targeted
cells. On the other hand, dendrimers represent the class of carrier system where massive control over size, shape and physicochemical
properties makes this delivery vector exceptional and favorable in genetic transfection applications. The siRNA therapeutics may be incorporated
inside the geometry of the density controlled dendrimers with the option of engineering the structure to the specific needs of
the genetic material and its indication. The existing reports on the siRNA carrying and deliverance potential of dendrimers clearly suggest
the significance of this novel class of polymeric architecture and certainly elevate the futuristic use of this highly branched vector as genetic
material delivery system.
