Title:Flavonoids with Therapeutic Potential in Prostate Cancer
Volume: 16
Issue: 10
Author(s): Bao Vue, Sheng Zhang and Qiao-Hong Chen
Affiliation:
Keywords:
Clinical study, flavonoid, in vivo efficacy, in vitro potency, mechanism of action, prostate cancer, structure-activity relationship.
Abstract: The term “flavonoids” is created for a large class of polyphenolic compounds
featuring two aromatic rings (A and B) and a central heterocyclic ring C. More than 4,000
flavonoids have already been obtained throughout the plant kingdom. An inverse correlation
between the intake of dietary flavonoids and the incidence of prostate cancer can be generally
well-observed from several epidemiological studies worldwide, which encouraged several
research groups to examine both in vitro and in vivo the potential of whole extracts of flavonoidenriched
dietary plants and purified flavonoids in preventing and treating prostate cancer. Nine
subclasses of naturally occurring dietary flavonoids have so far been explored and identified to
possess clinical potential in preventing and treating prostate cancer. We review herein the antiprostate
cancer potential (including in vitro potency, in vivo efficacy, and clinical studies),
structure-activity relationships, and the mechanism of actions of the nine subclasses of naturally
occurring flavonoids.
