Title:Nanosponge Carriers- An Archetype Swing in Cancer Therapy: A Comprehensive Review
Volume: 18
Issue: 1
Author(s): Riyaz Ali M. Osmani, Umme Hani, Rohit R. Bhosale, Parthasarathi K. Kulkarni and Seetharaman Shanmuganathan
Affiliation:
Keywords:
Bioavailability, cancer, cyclodextrin, cytotoxicity, nanosponges, targeted delivery.
Abstract: Nanotechnology and nanomedicines are emerging research meadows; which chiefly focuses
on creating and manipulating materials at a nanometer level for the betterment in imaging, diagnosis
and treatment of a range of diseases together with cancer. Cyclodextrin-based nanosponges, anticipated
as a new-fangled nanosized delivery system, are ground-breaking hyper-crosslinked cyclodextrin
polymers nanostructured within a three-dimensional network. Nanosponges based systems
hold the potential of elevating the solubility, absorption, penetration, bioavailability, in vivo stability,
targeted as well as sustained delivery, and therapeutic efficiency of numerous anticancer agents. The
extension of nanosponges based drug delivery systems is an exhilarating and demanding research pasture,
predominantly to overcome aforementioned problems allied to existing anticancer formulations
and for the further progressions in cancer therapies. Nanosponges in cancer therapy, particularly cyclodextrin
based nanosponges are brought up in this review. By quoting diverse attempts made in pertinent
direction, efforts have been made to exemplify the characteristics, suitability and versatility of
cyclodextrin based nanosponges for their promising applications in cancer treatment.
