Title:Carbazole Scaffold in Medicinal Chemistry and Natural Products: A Review from 2010-2015
Volume: 16
Issue: 11
Author(s): Lissa S. Tsutsumi, Daniela Gündisch and Dianqing Sun
Affiliation:
Keywords:
Biological activity, Carbazole, Natural product, SAR, Scaffold, Small molecule
Abstract: 9H-carbazole is an aromatic molecule that is tricyclic in nature, with two benzene rings
fused onto a 5-membered pyrrole ring. Obtained from natural sources or by synthetic routes, this scaffold
has gained much interest due to its wide range of biological activity upon modifications, including
antibacterial, antimalarial, anticancer, and anti-Alzheimer properties. This review reports a survey
of the literature on carbazole-containing molecules and their medicinal activities from 2010 through
2015. In particular, we focus on their in vitro and in vivo activities and summarize structure-activity
relationships (SAR), mechanisms of action, and/or cytotoxicity/selectivity findings when available to
provide future guidance for the development of clinically useful agents from this template.
