Title:Progress in Topical siRNA Delivery Approaches for Skin Disorders
Volume: 21
Issue: 31
Author(s): Mohammed Aldawsari, Mahavir B. Chougule and R. Jayachandra Babu
Affiliation:
Keywords:
siRNA, skin disorders, topical, nanoparticle.
Abstract: The topical application of therapeutic agent has shown promising efficacy in the treatment
of skin disorders. The siRNA based therapies have been used for treatment of various disorders
including skin diseases. The topical delivery of siRNA based therapies has opened new
perspectives for the treatment of skin disorders. The use of siRNA is limited due to the rapid
degradation and poor cellular uptake. Also, the stratum corneum, the top layer of skin is the major
barrier for the delivery of topical agents. There is unmet need for efficient topical formulation that will deliver the siRNA to the site of
action and also overcome the associated siRNA delivery limitations. The topical delivery of siRNA has been achieved using viral or nonviral
methods, and the combination of non-viral methods with an active permeation method such as iontophoresis, sonophoresis or microneedles
for the treatment of skin disorders. These delivery approaches have been tested in a preclinical setup and few cases the results
have shown promise for clinical trials. This review provides an update on the advances in the non-viral delivery approaches for siRNA
delivery for skin disorders and use of various delivery approaches for efficient delivery at the disease site.
